NGEF Antikörper
Kurzübersicht für NGEF Antikörper (ABIN7252975)
Target
Alle NGEF Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
-
-
Produktmerkmale
- Polyclonal Antibody
-
Aufreinigung
- Antigen affinity purification
-
Immunogen
- Fusion protein of human NGEF
-
Isotyp
- IgG
-
-
-
-
Applikationshinweise
- WB 1:500-1:2000, IHC 1:30-1:150, ELISA 1:5000-1:10000
-
Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
-
-
Format
- Liquid
-
Konzentration
- 0.6 mg/mL
-
Buffer
- PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4
-
Konservierungsmittel
- Sodium azide
-
Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Lagerung
- -20 °C
-
Informationen zur Lagerung
- Store at -20°C. Avoid freeze / thaw cycles.
-
-
- NGEF (Neuronal Guanine Nucleotide Exchange Factor (NGEF))
-
Andere Bezeichnung
- NGEF
-
Hintergrund
- Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity).
-
Molekulargewicht
-
Observed_MW: Refer to figures
Calculated_MW: 82 kDa
-
UniProt
- Q8N5V2
-
Pathways
- Neurotrophin Signalübertragung
Target
-